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Cell Transplantation Kinetics
You are given a dataset for blood platelet levels after transplantation of megakaryocytes (MK) for both intravenous and intra-bone routes. Assuming that 100% of fragmented platelets are derived from 100% transplanted MKs, determine MK decay kinetics:
i) Plot % MK decay (linear) vs Time (linear) and determine an appropriate curve fit – provide an equation with numbers. Note that you will have to do conversion from the given raw data. Determine half-life for each curve.
ii) Describe what this data tells us about differences between intravenous and intra-bone transplantation of MKs to generate platelets. Describe mechanisms behind how platelets may be generated from MKs via each route of transplantation, based on this data.