Neuroscience: Effects of Neuroanatomy and Neurotransmitters on HD


. What is the effect of GABA (gamma amino-butyric acid) on the nervous system? What does this do to membrane potential?

. How would this change in membrane potential affect action potentials and muscle movement?

. Would the loss of striatal neurons result in higher or lower GABA levels? Why might this lead to the symptoms observed with HD?