pharmacy biochem 1 –

Your team is in charge of selecting which of two new drugs should further be developed by the pharmaceutical company for which you work. Drug A is an acidic drug and Drug B is a basic drug. Both Drug A and Drug B show equal efficacy for inhibiting the activity of the enzyme HMG-CoA reductase. However, Drug B has a higher potency than Drug A when considering its ability to inhibit HMG-CoA reductase.

Based on these facts, which of the two drugs would you select to develop further?

Justify your answer below and include does-receptor curves for drug A and drug B.

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